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Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article

Men are also more likely to develop conditions associated with reduced glutathione or higher oxidative stress, including, More visceral fat than women, which drives insulin resistance 49 Higher rates of sleep apnea, another contributor to oxidative stress 50 Cardiovascular disease, which occurs about 710 years earlier in men than in women on average 51 As estrogen declines through perimenopause and menopause for womenand remains lower in men overalldifferences in glutathione activity likely reflect hormonal influence as much as sex-based biology, Tennant says

BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities

Under conditions of IL-13 stimulation, intracellular GSH levels (and hence GSH:GSSG) fall through 15LO1- and PEBP1-dependent reactions