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Neuregulin and IGF1 can act synergistically to increase mitochondrial biogenesis and mtDNA replication in primary Schwann cells, which requires both the ERK and PI3K signaling pathways (Ribeiro et al., 2014)

While an extreme lack of thiamin is unlikely and causes a disease called beriberi, even mild thiamin deficiency can lead to chronic weakness and fatigue

In contrast, higher magnesium consumption from dietary sources is considerably safe because it is digested more slowly and excreted by the kidneys

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