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Beyond direct H 2 O 2 scavenging, GSH also detoxifies lipid peroxidation byproducts, including malondialdehyde (MDA) and 4-HNE, through GST-mediated conjugation, facilitating their removal and preventing secondary cytotoxic signaling 91,92
From the perspective of transmembrane peptide design, there is still room for significant improvement in the future, including at least the following aspects: (1) integrating the ProteinMPNN deep learning model to expand the sequence space and achieve the synergistic optimisation of peptide length and sequence diversity
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