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[DOI] [PMC free article] [PubMed] [Google Scholar] Soerjomataram I, Bray F, 2021

This means: The same dose stops working as effectively Higher doses may be required (not sustainable) Side effects or inflammatory signals may increase Cellular response plateaus or worsens Strategic cycling allows receptors to reset, restore sensitivity, and respond optimally to the peptide

Specifically, the study reveals a significant reduction in serum melatonin levels in the model group compared to the control, suggesting the induction of stress

During pregnancy, your need for these nutrients increases