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These activated intermediates, including AACoA and AdACoA, are subsequently esterified into phospholipids by LPCAT3 [38],producing PUFA-enriched phosphatidylethanolamine species such as PE-AA and PE-AdA, which represent key substrates for lipid peroxidation during ferroptosis

Maintaining an optimal level of glutathione appears to be important for supporting cognitive function, especially during aging.* The normal process of aging is associated with a decrease in glutathione activity, which can result in increased oxidative activity.* Less than an optimum level of glutathione is observed in individuals experiencing a decline in cognitive function.* Conversely, individuals who live to 100 tend to have higher glutathione activity.*

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Sham-operated rats received isotonic saline both arterially and intraductally

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