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However, these data also raise critical mechanistic and structural questions on how the different small molecule agonist engage and activate the GLP-1R, and in particular with respect to how PF 06882961 can mimic key properties of the native peptide

Genetic alterations, such as CDKN2A mutation, RPLP1-C19MC fusion, and chromosomal changes like 1p loss and 7q gain, highlight the molecular heterogeneity of MNTI and its possible overlap with other embryonal tumors, like neuroblastoma (Almomani and Rentea 2021)

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