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Riboflavin deficiency can result in decreased xanthine oxidase activity, reducing blood uric acid levels (6)
In Phase 3 clinical research, this combination has been examined for coordinated effects on appetite regulation, glucose metabolism, and metabolic balance
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Other AEs reported with SGLT2i use include osmotic diuresis-related events and volume depletion-related hypotension, the latter of which tends to be more common in older adults, people with an eGFR of 3060 mL/min/1.73 m 2 , and in those taking loop diuretics [4]
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