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Dosage: Studies have used 100 mg/kg/day on an empty stomach Safety: May cause headaches or insomnia at high doses

Hydroquinone-induced exogenous ochronosis is a potential side effect which when present, is difficult to treat

349 If the ulcers fail to show a 50% reduction after 4 weeks of appropriate management via conventional methods, several advanced therapies, including negative-pressure therapy, growth factor therapy, bioengineered tissue, acellular matrix tissue, stem cell therapy, hyperbaric oxygen therapy, and, most recently, topical oxygen therapy, can be considered

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