If you introduce a peptide into your body that contains heavy metals or bacterial byproducts, you will actually trigger an M1 (inflammatory) responsethe exact opposite of what you are trying to achieve
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Jakubowski AA, Gordon M, Moore MAS, Tafuri A, Andreeff M , Shieh JH, Brown S, Vincent M, Gabrilove JL
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The microbiome-gut-brain content axis consists of three bidirectional, biochemical, signaling pathways between the gut and the brain, and these three pathways include the nervous, endocrine, and immune pathways (198)