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International note Retatrutide is also not approved in the UK, EU, Australia, Canada, or any other major market as of June 2026

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For severe hypertriglyceridemia (500 mg/dL), fibrates or prescription omega-3 fatty acids (icosapent ethyl) remain first-line to prevent pancreatitis, though GLP-1 therapy may provide additional benefit in appropriate patients

Risk ratios (RR) for MACE estimates according to direct (DPP-4 inhibitors, GLP-1RA and SGLT-2 inhibitors against placebo) and indirect (DPP-4 inhibitors vs GLP-1RA or SGLT-2 inhibitors, and GLP-1RA vs SGLT-2 inhibitors) comparisons

Higher app engagement was associated with greater weight loss