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Studies in the Journal of Clinical Investigation demonstrate CJC-1295 with DAC increases IGF-1 levels by 200-300% for up to one week after a single injection

The BDNF fragment (aa 104-115) is critical for BDNF-TLR4 interaction, and the corresponding synthetic BDNF-derived dodecapeptide (BDP-12) retains TLR4-antagonistic and anti-inflammatory effects both in vitro and in vivo, without pro-proliferative side effects

10.1038/tp.2012.61 [DOI] [PMC free article] [PubMed] [Google Scholar] Rossato JI, Bevilaqua LRM, Izquierdo I, Medina JH, Cammarota M (2009) Dopamine controls persistence of long-term memory storage

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The synthetic fragment captures the key functional sequences responsible for TB-500's regenerative properties while offering improved stability and standardized production