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Transporters for GCs at the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB) have emerged as substantial contributors to GCs distribution in the brain

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When to Contact Your Doctor Temperature consistently above 38.5C on injection days Palpitations or chest discomfort accompanying flushing Symptoms worsening rather than stabilizing over the first 48 weeks Any doubt about whether what you're experiencing is the expected thermogenic effect or something else How Temperature Changes Evolve Over Time Based on the known pharmacology of glucagon and the dose titration schedule used in TRIUMPH trials: Weeks 14 (low dose, 2mg): Minimal thermogenic effect