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High-resolution approaches, including super-resolution microscopy, electron tomography, and emerging ovarian three-dimensional imaging techniques, can be applied to age-stratified ovarian samples to quantitatively map changes in mitochondria-ER, mitochondria-lysosome, mitochondria-peroxisome, and mitochondria-lipid droplet contact sites in oocytes and granulosa cells

Nick Gilpin, RSA Program Committee Co-Chair, who emphasized the power of interdisciplinary collaboration

No, it is not recommended during pregnancy or breastfeeding

Based on these data, women who are considering becoming pregnant are now recommended to avoid using high-dose VPA by switching to other antiepileptic drugs or reducing VPA to dose to 600 mg/day or less before pregnancy (35)

Mitochondrial dysfunction has been identified in a subset of individuals with ASD utilizing biochemical markers, clinical criteria, direct enzyme assay, and molecular methods