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Following discovery of a sparse number of occurrences of progressive multifocal leukoencephalopathy (PML) in those taking a FAE, median duration of FAE therapy to PML symptom onset or appearance of first PML brain lesion was 31 months (range 6110), with median duration of lymphocytopenia to PML symptoms being 23 months (range 672)

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Nonetheless, gastrointestinal side effects led to treatment discontinuation in 4.5% of participants in semaglutide trials and 6.2% of those receiving the highest dose (15 mg weekly) of tirzepatide