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No developmental effects were observed in rabbits at 300 mg/kg/day resulting in systemic exposure (AUC24) approximately 3 times higher than clinical exposures at the approved human dose of PAXLOVID

Additionally, GLP-1 signaling influences calcitonin gene-related peptide (CGRP), a neuropeptide strongly implicated in migraine pathophysiologythe same target that newer migraine-specific medications like erenumab address

Participants will be randomized 3:2 to receive either 90 mg of avexitide subcutaneously once daily or placebo

Scientifically, the answer is that no single plan suits everyone

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