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Nature 572: 397401, 2019

Having moderate to severe diabetic retinopathy before starting the medication A history of poorly controlled blood sugar over many years High blood pressure that is not well managed Kidney disease or other diabetes-related complications Very rapid reduction in hemoglobin A1C levels within the first few months Rare cases of sudden, painless vision loss from optic nerve injury have been reported in people using GLP-1 receptor agonist medications

treatment difference 8.7%