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The first generation of drugs had minimal weight loss benefits

For acute injuries, the traditional RICE protocol (rest, ice, compression, elevation) emphasizes immediate cold application during the first 48 hours when inflammatory processes are most active

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Two randomized control clinical trials reported conflicting effects on bone mineral content (BMC) and bone mineral density (BMD): one trial demonstrated preservation of BMC with GLP-1 use, while the other found no significant difference in BMC or BMD between treatment and control groups