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Featuring 94% sequence homology to endogenous human GLP-1, this 31-amino acid polypeptide incorporates two critical structural modifications: an aminoisobutyric acid (Aib) substitution at position 8 to prevent degradation by the DPP-4 enzyme, and the attachment of a C18 fatty diacid via a hydrophilic spacer

Switching between brands may affect tolerability even with identical active ingredient concentrations

And a small percentage never experience meaningful side effects at all

Dutta P, Kumar Y, Babu AT, Ravindran SG, Salam A, Rai B, Baskar A, Dhawan A, Jomy M

In rare cases, thoughts of self-harm have been reported