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Described as the first selective GHRP-receptor agonist. Bone Biology 1999 Bone-growth dissociated from IGF-1 (15-day rat model) Johansen and colleagues reported dose-dependent increases in longitudinal bone-growth rate in adult female rats after 15 days of ipamorelin administration, with total IGF-I and IGFBPs unchanged a dissociation of skeletal effects from the sustained IGF-1 axis in this short-duration preclinical model