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When you stop a GLP-1 medication, the drug clears your system based on its half-life

Sustained GHRHR activation by CJC-1295 with DAC could theoretically cause receptor downregulation or feedback suppression of endogenous GHRH release

Clinical trials for GLP-1 agonists have reported musculoskeletal side effects such as back pain and muscle pain in a small percentage of participants, but joint pain specifically has not emerged as a consistent or significant adverse event across the class