In dogs, supplementation has been associated with improved exercise performance and recovery in certain contexts, likely by supporting energy availability during activity
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Pain is especially worse in the middle of the night
For GLP-1 medications, data was only available for a year after the drugs were stopped, with the overall projections based on follow-ups up to 52 weeks
Serious deficiency can cause a disease called scurvy, though it's very rare in the U.S