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J Autoimmun (2011) 36(3-4):189200

The implications for conditions involving compromised blood flow are significant, though human confirmation of this mechanism remains needed

MTHFR variants and methylation dysfunction have been implicated in: Depression and anxiety Bipolar disorder Schizophrenia Chronic fatigue and fibromyalgia Recurrent pregnancy loss and infertility Cardiovascular and cerebrovascular disease Neurodegenerative disorders such as Alzheimers disease Supporting methylation through targeted nutrition and appropriate forms of folate can improve neurotransmitter synthesis, reduce oxidative stress, and enhance overall neurological stability