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To this end, we monitored the response of NAPstar3b in HEK293 cells and in HEK293 cells with a CRISPR-Cas9-mediated disruption of GSR (encoding glutathione reductase)

Drug Discov Today 26:916930 La Rosa P, Petrillo S, Fiorenza MT, Bertini ES, Piemonte F (2020) Ferroptosis in Friedreichs ataxia: a metal-induced neurodegenerative disease

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Figure 2 Following approximately a month of hospitalization in the surgical department, a dermatological consultation was sought, leading to the initiation of treatment with methylprednisolone 0.5 mg/kg/day for 4 weeks then tapered to 5 mg/day

Monoubiquitination typically modulates protein activity, localization, interaction partners, and endocytic trafficking [68], whereas K63-linked polyubiquitination mediates signal transduction pathways and K48-linked polyubiquitination targets substrates for proteasomal degradation [66, 67]