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These studies show that metastatic cancer cells in lymph nodes compared to cancer cells from the primary tumor undergo metabolomic and lipidomic alterations that confer survival advantages for metastasis

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In sepsis-induced cardiac dysfunction, GLPs activate the SIRT1 pathwaya effect that is abolished by the selective SIRT1 inhibitor EX-527leading to marked anti-inflammatory actions (reduced levels of IL-1, IL-6, TNF-, CK-MB, LDH, and diminished inflammatory cell infiltration), inhibition of cardiomyocyte apoptosis (downregulation of caspase-3, caspase-9, and Bax

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Jacob Murphy is a graduating medical student from Johns Hopkins, where he will also complete his internal medicine residency