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The compound long half-life means effects persist for several weeks after the last administration, which must be factored into any pause or discontinuation decision

GLP-2 and GIP exert separate effects on bone turnover: A randomised, placebo-controlled, crossover study in healthy young men

Of those entering the study, 14 had normal renal function, 11 had mild RI, 11 had moderate RI, ten had severe RI, and ten had ESRD requiring hemodialysis

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