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GLP-1R, when activated, initiates downstream signaling effects that lead to an overall decrease in blood glucose levels, including potentiation of insulin secretion, reduced glucagon secretion, and weight loss via satiety induction that results in increased insulin sensitivity (2)

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Natural strategies like high-fiber foods, fermented goods, adequate protein, and regular exercise can modestly increase GLP-1 production

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In the presence of GI AEs, one of the first precautions recommended is to extend the titration period or delay dose escalation until symptoms subside