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As the glycine in position 2 of our analogues prevents the specific DDP-4 cleavage between residues 2 and 3, our attention was turned toward the later

Butyrate enhances the quantity of regulatory T cells (Tregs) in the gastrointestinal tract and bone marrow (106), upregulates the VitD receptor (VDR), and alters proteins associated with calcium absorption, therefore affecting bone metabolism (107)

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