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Acknowledgements Editorial Staff Elizabeth Jean Betsch, ELS Amy Zierler, BA Medical Information Services Corinne Holubowich, BEd, MLIS Kellee Kaulback, BA(H), MISt Clinical Expert Advisory Panel: Appropriate Utilization of Vitamin B12 Testing for Neurocognitive-Based Indications

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Combining MOTS-c with 5-Amino-1MQ creates synergistic metabolic enhancement by targeting two distinct but complementary pathways: MOTS-c activates AMPK to increase mitochondrial biogenesis and insulin sensitivity, while 5-Amino-1MQ inhibits NNMT to preserve NAD+ levels, which fuel the very pathways MOTS-c activates