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As further proof, we inhibited transketolase (non-oxPPP) activity by oxythiamine and observed a decrease in UMP m+2 labelling in both genotypes, but only WT chondrocytes showed an upregulation of UMP m+1 labelling, indicating that only WT cells could increase oxPPP activity as compensation (Extended Data Fig

Introduction of shRNA to knock down ACTL6A expression inhibited the wound healing and metastatic ability of GC cells (Fig