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The metabolic benefits persist as long as the lean mass is maintained

The UK's Medicines and Healthcare products Regulatory Agency (MHRA) logged adverse reactions to Melanotan II and warned the public of serious health risks. The UK agency is also concerned that MT-II is increasingly being marketed to younger consumers with bright colors and branding and has been focused on removing UK-facing sales websites advertising MT-II since 2011

There is also debate as to the best delivery system, whether liposomal, oral, or intravenous

In one study, GPLC was provided to previously sedentary men and women who were also assigned to supervised aerobic exercise for eight weeks