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However, large-scale randomized controlled trials in humans are absent, limiting evidence for clinical safety and efficacy claims

"Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers." PLoS ONE , vol

The potential biomarkers analyzed included DNA polymorphisms, gene expression levels quantified as mRNA and proteins, and metabolites, as well as methylation markers, microRNAs, and malignant primary circulating prostate cells

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However, those with sensitive skin should patch test any new glutathione product before full application