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Multiple studies found that the C+E combo raised the sunburn threshold and reduced UV-induced skin redness, whereas vitamin C on its own was insufficient

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Also, bile acids metabolism has been described as involved in atherosclerosis development: it is probably related to bacterial bile salt hydrolyzation, which can stimulate enlargement of atherosclerotic plaque through cholesterol accumulation and foam cell formation [68]

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By contrast, routine initiation is generally not indicated for lean PCOS or for patients with low cardiometabolic risk, except in selected circumstances (e.g., specific metabolic indications) or within research protocols