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However, given the central role of the thyroid in metabolic regulation, any changes in body weight or metabolism due to semaglutide could theoretically influence thyroid hormone levels or the bodys response to thyroid medication

Constipation: Occurred in 18.8% of patients on semaglutide in the STEP-1 trial, compared to 6.8% in the placebo group

The administration of ghrelin to rats deprived of food before refeeding prevents the downregulation of MCH and CB-1 receptors in VANs, suggesting that ghrelin mediates the expression of orexigenic receptors to induce food intake (90)

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This, therefore, appears to imply an uncertainty regarding sKlotho as a possible biomarker in CKD and represents an area of continuing investigation