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10.1126/sciadv.abn6027 75 JiangT.ChengH.SuJ.WangX.WangQ.ChuJ.et al (2020)

Clinical Evidence Semaglutide: proof of concept for high-efficacy GLP-1 therapy Semaglutide 2.4 mg established that selective GLP-1 receptor agonism could produce substantial weight loss in adults with obesity

Visible improvement normally happens within 48 weeks of regular use