If they know what to expect, they can identify side effects early and persevere
Retatrutide at 12mg produced approximately 24% weight loss at 48 weeks compared to tirzepatide at 15mg producing approximately 22% at 72 weeks
PubMed Finan, B., Yang, B., Ottaway, N., Smiley, D.L., Ma, T., Clemmensen, C., Chabenne, J., Zhang, L., Habegger, K.M., Fischer, K., Campbell, J.E., Sandoval, D., Seeley, R.J., Bleicher, K., Uhles, S., Riboulet, W., Funk, J., Hertel, C., Belli, S., Sebokova, E., Conde-Knape, K., Konkar, A., Drucker, D.J., Gelfanov, V., Pfluger, P.T., Mller, T.D., Perez-Tilve, D., DiMarchi, R.D., & Tschp, M.H
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The added glucagon arm is thought to raise energy expenditure on top of the appetite reduction driven by GIP and GLP-1[3]