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Approximately 1.1 billion compounds were screened via this platform, and multiple candidate compounds with geroprotective properties that demonstrate structural novelty and target specificity were successfully identified
S2CID 1024446
December 21, 2022)
Lipogenesis induction by nutrients is also mediated by the carbohydrate response element-binding protein (ChREBP), PPAR coactivator 1-, and liver X receptor-mediated SREBP-1c [45-47], and these alternative pathways of lipogenesis have been shown to be activated by fructose and monosaccharides [48,49]
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