Follow the instructions printed on the prescription label
To the contrary, they seem to be patting themselves on the back for even including any data at all on these premature cardiac deaths, stating: "If our primary endpoint had focused exclusively on the onset of CHF, with dogs that died being censored, it might have appeared that we were choosing to ignore potentially detrimental effects of the treatment." Well, it certainly does appear that they have chosen to ignore those detrimental effects
For reference, phentermine can be prescribed separately as a short-term weight loss medication, but its also available in a combination medication with topiramate (Qsymia) for long-term use
According to the clinical expert consulted by CADTH on this review, there is a lack of structured weight management programs that are financially accessible to patients in Canada
However, the most effective approach is not choosing one over the other, but understanding how they work together