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A researcher administering 300 mcg twice daily is working with a fundamentally different pharmacokinetic profile than one administering 200 mcg three times daily, even though the total daily exposure might be similar

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Psychological therapies such as cognitive-behavior therapy and gut-directed hypnotherapy also appears to be beneficial in reducing abdominal pain as they aim to address the psychological aspects of pain and improve coping mechanisms, but more high-quality evidence is needed [120]