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Clinical Trial Results SURMOUNT-1 trial: Average weight loss of ~20% of total body weight

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Analysis of the mice' bone marrow cells, precursors of the monocytes, showed upregulation of proinflammatory cathepsin protein family (CatB and CatZ), which was later terminated during bone marrow differentiation to the macrophages

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16 Furthermore, disintegration and absorption of the oral semaglutide dosage form in the stomach seem to ensue via a localized process where the tablet initially makes contact with the stomach wall