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The CagriSema program, combining cagrilintide with semaglutide, has demonstrated: 15.1% mean body weight reduction at 32 weeks in REDEFINE 1 trial Approximately 15-17% weight loss in various phase 3 timepoints Superior outcomes compared to semaglutide monotherapy Manageable safety profile with expected GI side effects Cagrilintide 10mg remains an important research tool for scientists exploring amylin analogue applications

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The available scientific information in relation to the quantification of BDNF isoforms in human samples is scarce, and the studies have primarily focused on populations with neurological problems due to the added value of BDNF as a biomarker in these pathologies (Supplementary Table S1)