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doi: 10.1016/j.jacl.2021.05.007 268 WongCKMcLeanBABaggioLLKoehlerJAHammoudRRittigNet al

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IGF-1 DES: Demonstrates the highest selectivity for the IGF-1 receptor among IGF-1 analogues

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Activation of the peripheral nervous system likely occurs primarily through stimulation of the hepatic vagal nerve in the portal area

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Compared to the corresponding endogenous hormones, retatrutide is more potent at GIPR by a factor of 8.9, and less potent at GCGR and GLP-1R by factors of 0.3 and 0.4, respectively 7 (Fig

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