At the same time, SIRT1 deacetylates multiple transcription factors, such as Nrf2, promotes its entry into the nucleus and activates the expression of antioxidant stress genes, such as HO-1 and GPX4, the activation of which helps mitigate cell damage caused by ferroptosis
Hyperandrogenemia, characterized by an elevated LH/FSH ratio, represents a significant hormonal derangement in patients living with infertility and PCOS [38]
Moreover, clinical studies have shown associations between cannabis use and shifts in the gut microbial community, particularly in relation to the abundance of certain bacterial communities [13,85]
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