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The product is likewise indicated for increased physiologic demand (pregnancy, thyrotoxicosis, chronic hemorrhage), for drug-induced depletion, and for select neurologic or hematologic disorders in which B12 plays a pivotal metabolic role

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Furthermore, melatonin has been used in several tissues to reduce the calcium uptake by the cells and modulate the expression of antioxidants [4,8,22,23,24,25,26,27]