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Zito et al., 2010)

Different rationale, equally sound mechanistic logic

Critics counter that moving the compounds into legitimate pharmacies could create the appearance that they have been proved safe and effective when, in many cases, data from robust clinical trials remains limited

Pulsatility is thought to matter for the downstream physiological effects of GH, which is part of why research models favor a short GHRH signal (no-DAC) that reinforces natural pulses over a multi-day DAC signal that raises the baseline more persistently

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