"In the brain, it's thought to reduce food intake by some element of appetite suppression," says Evan Nadler, MD, MBA , former co-director of the obesity program at Children's National Hospital and current adjunct associate professor at George Washington University
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Recent studies have revealed that OXPHOS-dominant subpopulations, while reliant on mitochondrial energy production, exhibit marked sensitivity to complex I inhibitors such as IACS-010759
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The primary effect of these medications is usually to reduce appetite, leading to a gradual decrease in weight over time as patients consume fewer calories