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The accumulated methylation occurred on CGs overlapping with the Egr1/NGFI-A/Zif268/Krox-24-binding sequence that is positioned close to the putative binding sites of Neurogenins (Ngn), neuronal determination factors that directly stimulate expression of NeuroD1 (Bertrand et al., 2002)

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Similarly, the treatment of lung cancer cells with CB-839, which reduces glutaminase activity in tumors, also results in signs of reduced tumor growth [70]