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They also mention that tesofensine at 0.5 mg causes twice the weight loss observed with sibutramine and rimonabant

I don't agree that's the case

It has been found to exert a wide array of beneficial effects, including anti-inflammatory properties and the ability to promote angiogenesis (the formation of new blood vessels), which is crucial for tissue repair and regeneration

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It inhibits an enzyme called NNMT which means it helps unlock the bodys fat-burning potential , rev up cellular energy , and protect your brain and muscles from age-related decline