hengrui glp-1 China Medicine has registered a Phase III, multicenter, randomized, double-blind clinical trial of the GLP-1R/GIPR dual agonist HRS9531 for the treatment of obesity (NCT06396429; HRS9531-301) Kailera says obesity pill succeeds

In the SURMOUNT-1 trial, tirzepatide produced average weight reductions of 15.0%, 19.5%, and 20.9% at studied doses compared with 3.1% with placebo over 72 weeks

Miguens-Gomez et al 2021)

[2] The takeaway for anyone interested in gut health is simple but powerful: because L-cells respond to signals arriving from the gut lumen, the environment inside your intestine including the composition and activity of your microbiome is directly upstream of how much GLP-1 gets made

They typically contain prebiotic fiber (resistant starch, Fibersol), probiotics ( Akkermansia muciniphila , Bifidobacterium strains), or metabolic compounds (berberine, chromium picolinate, 5-HTP, saffron extract)

With a GLP-1 fusion protein containing an albumin binding domain, Yousefpour and colleagues 61 showed that the longer length and rigidity of the helical linker effectively kept the albumin, which is bound to the albumin binding domain, far enough from GLP1 to prevent it from interfering with its binding to the GLP1-R