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There were substantial heterogeneities with within-run variation ranging from 4% to 32% among three commercial assays, indicating the uncertainty of ELISA assays (Heijboer et al., 2013)

In SURMOUNT-1, adults with obesity (without diabetes) lost an average of 15.0%, 19.5%, and 20.9% of body weight with tirzepatide 5 mg, 10 mg, and 15 mg respectively over 72 weeks, compared to 3.1% with placebo

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