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Endocrinology 147 , 37273736

It seems irresponsible to assume that if we pull one level over here, it would not impact another lever over there

It is becoming increasingly obvious that treating obesity also requires a multimodal approach that combines lifestyle interventions, pharmacotherapy, and bariatric surgery to achieve the tailored weight loss and metabolism goals needed for long-term health gain

Additional trials are also underway in participants with type 1 diabetes targeting diverse pathways including oxidative stress, using nicotinamide adenine dinucleotide phosphate oxidase (Nox)-1/4 inhibitors, and the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, using bardoxolone (NCT03366337, NCT03550443) [84, 85]

References Graaf, C